Functional Assessment of 12 Rare Allelic <i>CYP2C9</i> Variants Identified in a Population of 4773 Japanese Individuals

Functional Assessment of 12 Rare Allelic <i>CYP2C9</i> Variants Identified in a Population of 4773 Japanese Individuals

Cytochrome P450 2C9 (CYP2C9) is an important drug-metabolizing enzyme that contributes to the metabolism of approximately 15% of clinically used drugs, including warfarin, which is known for its narrow therapeutic window. Interindividual differences in CYP2C9 enzymatic activity caused by <i>CY...

Full description

Bibliographic Details
Main Authors: Masaki Kumondai, Akio Ito, Evelyn Marie Gutiérrez Rico, Eiji Hishinuma, Akiko Ueda, Sakae Saito, Tomoki Nakayoshi, Akifumi Oda, Shu Tadaka, Kengo Kinoshita, Masamitsu Maekawa, Nariyasu Mano, Noriyasu Hirasawa, Masahiro Hiratsuka
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Journal of Personalized Medicine
Subjects:
cytochrome P450 2C9
genetic variation
(<i>S</i>)-warfarin
tolbutamide
drug metabolism
Online Access:https://www.mdpi.com/2075-4426/11/2/94

Internet

https://www.mdpi.com/2075-4426/11/2/94

Similar Items