Amyloid precursor protein glycosylation is altered in the brain of patients with Alzheimer’s disease

Amyloid precursor protein glycosylation is altered in the brain of patients with Alzheimer’s disease

Abstract Background The amyloid precursor protein (APP) is a transmembrane glycoprotein that undergoes alternative proteolytic processing. Its processing through the amyloidogenic pathway originates a large sAPPβ ectodomain fragment and the β-amyloid peptide, while non-amyloidogenic processing gener...

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Bibliographic Details
Main Authors: Claudia P. Boix, Inmaculada Lopez-Font, Inmaculada Cuchillo-Ibañez, Javier Sáez-Valero
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
sAPPα
sAPPβ
Brain
Glycosylation
Online Access:http://link.springer.com/article/10.1186/s13195-020-00664-9

Internet

http://link.springer.com/article/10.1186/s13195-020-00664-9

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