Amyloid precursor protein glycosylation is altered in the brain of patients with Alzheimer’s disease
Abstract Background The amyloid precursor protein (APP) is a transmembrane glycoprotein that undergoes alternative proteolytic processing. Its processing through the amyloidogenic pathway originates a large sAPPβ ectodomain fragment and the β-amyloid peptide, while non-amyloidogenic processing gener...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2020-08-01
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Series: | Alzheimer’s Research & Therapy |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13195-020-00664-9 |