THBS1/CD47 Modulates the Interaction of γ-Catenin With E-Cadherin and Participates in Epithelial–Mesenchymal Transformation in Lipid Nephrotoxicity

THBS1/CD47 Modulates the Interaction of γ-Catenin With E-Cadherin and Participates in Epithelial–Mesenchymal Transformation in Lipid Nephrotoxicity

Hyperlipidemia, an important risk factor for cardiovascular and end-stage renal diseases, often aggravates renal injury and compromises kidney function. Here, histological analysis of human kidney samples revealed that high lipid levels induced the development of renal fibrosis. To elucidate the mec...

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Bibliographic Details
Main Authors: Li Gao, Ting-ting Yang, Jun-sheng Zhang, Hong-xia Liu, Dong-cheng Cai, Lin-tao Wang, Jing Wang, Xin-wei Li, Kun Gao, Su-ya Zhang, Yu-jia Cao, Xiao-xia Ji, Miao-miao Yang, Biao Han, Sheng Wang, Lu He, Xiao-yan Nie, Dan-mei Liu, Gang Meng, Chao-yong He
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
cd47
E-cadherin
γ-catenin
fibrosis
inflammation
lipid nephrotoxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.601521/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.601521/full

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