Ncx3-Induced Mitochondrial Dysfunction in Midbrain Leads to Neuroinflammation in Striatum of A53t-α-Synuclein Transgenic Old Mice

Ncx3-Induced Mitochondrial Dysfunction in Midbrain Leads to Neuroinflammation in Striatum of A53t-α-Synuclein Transgenic Old Mice

The exact mechanism underlying selective dopaminergic neurodegeneration is not completely understood. The complex interplay among toxic alpha-synuclein aggregates, oxidative stress, altered intracellular Ca<sup>2+</sup>-homeostasis, mitochondrial dysfunction and disruption of mitochondri...

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Bibliographic Details
Main Authors: Rossana Di Martino, Maria Josè Sisalli, Rossana Sirabella, Salvatore Della Notte, Domenica Borzacchiello, Antonio Feliciello, Lucio Annunziato, Antonella Scorziello
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
Parkinson’s disease
mitochondrial dysfunction
neuroinflammation
α-synuclein
Online Access:https://www.mdpi.com/1422-0067/22/15/8177

Internet

https://www.mdpi.com/1422-0067/22/15/8177

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