Generation of Human CRY1 and CRY2 Knockout Cells Using Duplex CRISPR/Cas9 Technology

Generation of Human CRY1 and CRY2 Knockout Cells Using Duplex CRISPR/Cas9 Technology

Circadian clocks are endogenous oscillators essential for orchestrating daily rhythms in physiology, metabolism and behavior. While mouse models have been instrumental to elucidate the molecular mechanism of circadian rhythm generation, our knowledge about the molecular makeup of circadian oscillato...

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Bibliographic Details
Main Authors: Teresa Börding, Ashraf N. Abdo, Bert Maier, Christian Gabriel, Achim Kramer
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Physiology
Subjects:
circadian
CRISPR/Cas9
cryptochrome
U-2 OS
duplex
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00577/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.00577/full

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