Global Nav1.7 knockout mice recapitulate the phenotype of human congenital indifference to pain.

Global Nav1.7 knockout mice recapitulate the phenotype of human congenital indifference to pain.

Clinical genetic studies have shown that loss of Nav1.7 function leads to the complete loss of acute pain perception. The global deletion is reported lethal in mice, however, and studies of mice with promoter-specific deletions of Nav1.7 have suggested that the role of Nav1.7 in pain transduction de...

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Bibliographic Details
Main Authors: Jacinthe Gingras, Sarah Smith, David J Matson, Danielle Johnson, Kim Nye, Lauren Couture, Elma Feric, Ruoyuan Yin, Bryan D Moyer, Matthew L Peterson, James B Rottman, Rudolph J Beiler, Annika B Malmberg, Stefan I McDonough
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4154897?pdf=render

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http://europepmc.org/articles/PMC4154897?pdf=render

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