Combination of Metformin, Sodium Oxamate and Doxorubicin Induces Apoptosis and Autophagy in Colorectal Cancer Cells via Downregulation HIF-1α

Combination of Metformin, Sodium Oxamate and Doxorubicin Induces Apoptosis and Autophagy in Colorectal Cancer Cells via Downregulation HIF-1α

Colorectal cancer (CRC) is the third leading cause of cancer-related death worldwide in both sexes. Current therapies include surgery, chemotherapy, and targeted therapy; however, prolonged exposure to chemical agents induces toxicity in patients and drug resistance. So, we implemented a therapeutic...

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Bibliographic Details
Main Authors: Jossimar Coronel-Hernández, Rebeca Salgado-García, David Cantú-De León, Nadia Jacobo-Herrera, Oliver Millan-Catalan, Izamary Delgado-Waldo, Alma D. Campos-Parra, Miguel Rodríguez-Morales, Norma L. Delgado-Buenrostro, Carlos Pérez-Plasencia
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Oncology
Subjects:
HIF-1α
autophagy
ULK1
mir-26a
AKT
proliferation
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.594200/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.594200/full

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