Physiologically-based toxicokinetic modeling of zearalenone and its metabolites: application to the Jersey girl study.

Zearalenone (ZEA), a fungal mycotoxin, and its metabolite zeranol (ZAL) are known estrogen agonists in mammals, and are found as contaminants in food. Zeranol, which is more potent than ZEA and comparable in potency to estradiol, is also added as a growth additive in beef in the US and Canada. This...

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Bibliographic Details
Main Authors: Dwaipayan Mukherjee, Steven G Royce, Jocelyn A Alexander, Brian Buckley, Sastry S Isukapalli, Elisa V Bandera, Helmut Zarbl, Panos G Georgopoulos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4256163?pdf=render