Mitochondrial control of innate immune signaling by irradiated cancer cells

Mitochondrial control of innate immune signaling by irradiated cancer cells

Type I interferon (IFN) release by irradiated cancer cells is paramount for radiation therapy to elicit anticancer immunity. Our findings demonstrate that mitochondrial outer membrane permeabilization (MOMP) triggered by RT enables exposure of mitochondrial DNA to the cytosol, hence setting off CGAS...

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Bibliographic Details
Main Authors: Takahiro Yamazaki, Lorenzo Galluzzi
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:OncoImmunology
Subjects:
abscopal responses
autophagy
caspases
immunogenic cell death
micronuclei
sting
venetoclax
Online Access:http://dx.doi.org/10.1080/2162402X.2020.1797292

Internet

http://dx.doi.org/10.1080/2162402X.2020.1797292

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