PU.1-Silenced Dendritic Cells Induce Mixed Chimerism and Alleviate Intestinal Transplant Rejection in Rats via a Th1 to Th2 Shift

PU.1-Silenced Dendritic Cells Induce Mixed Chimerism and Alleviate Intestinal Transplant Rejection in Rats via a Th1 to Th2 Shift

Background/Aims: Intestinal transplantation is an effective treatment for end-stage bowel failure; however, graft rejection and the toxicity associated with non-specific immunosuppression are major limitations of this procedure. Studies have shown that mixed chimerism can produce post-transplantatio...

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Bibliographic Details
Main Authors: Xingwei Xu, Xin Gao, Xiaofan Zhao, Yannian Liao, Wu Ji, Qiurong Li, Jieshou Li
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-01-01
Series:Cellular Physiology and Biochemistry
Subjects:
PU.1
Chimerism
Immune
Intestinal transplantation
Online Access:http://www.karger.com/Article/FullText/438623

Internet

http://www.karger.com/Article/FullText/438623

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