Effect of CRISPR/Cas9-Mediated PD-1-Disrupted Primary Human Third-Generation CAR-T Cells Targeting EGFRvIII on In Vitro Human Glioblastoma Cell Growth

Effect of CRISPR/Cas9-Mediated PD-1-Disrupted Primary Human Third-Generation CAR-T Cells Targeting EGFRvIII on In Vitro Human Glioblastoma Cell Growth

Glioblastoma (GBM), which is the most common malignant brain tumor, is resistant to standard treatments. Immunotherapy might be a promising alternative for the treatment of this cancer. Chimeric antigen receptor (CAR) is an artificially modified fusion protein that can be engineered to direct the sp...

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Bibliographic Details
Main Authors: Tsutomu Nakazawa, Atsushi Natsume, Fumihiko Nishimura, Takayuki Morimoto, Ryosuke Matsuda, Mitsutoshi Nakamura, Shuichi Yamada, Ichiro Nakagawa, Yasushi Motoyama, Young-Soo Park, Takahiro Tsujimura, Toshihiko Wakabayashi, Hiroyuki Nakase
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
CAR
CRISPR/Cas9
EGFRvIII
PD-1
glioblastoma
Online Access:https://www.mdpi.com/2073-4409/9/4/998

Internet

https://www.mdpi.com/2073-4409/9/4/998

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