The impact of the tumor shrinkage by initial EGFR inhibitors according to the detection of EGFR-T790M mutation in patients with non-small cell lung cancer harboring EGFR mutations

The impact of the tumor shrinkage by initial EGFR inhibitors according to the detection of EGFR-T790M mutation in patients with non-small cell lung cancer harboring EGFR mutations

Abstract Background The EGFR-T790M mutation is clinically detected using re-biopsy in approximately 50% of patients with acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in advanced non-small cell lung cancer (NSCLC) who harbor EGFR mutations. However, l...

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Bibliographic Details
Main Authors: Akihiro Yoshimura, Tadaaki Yamada, Naoko Okura, Takayuki Takeda, Wataru Furutani, Yutaka Kubota, Shinsuke Shiotsu, Osamu Hiranuma, Naoya Nishioka, Yusuke Chihara, Nobuyo Tamiya, Yoshiko Kaneko, Junji Uchino, Koichi Takayama
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BMC Cancer
Subjects:
EGFR-T790M mutation
Non-small cell lung cancer
Re-biopsy
Tumor shrinkage
Online Access:http://link.springer.com/article/10.1186/s12885-018-5153-4

Internet

http://link.springer.com/article/10.1186/s12885-018-5153-4

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