AhR Activation Underlies the CYP1A Autoinduction by A-998679 in Rats

AhR Activation Underlies the CYP1A Autoinduction by A-998679 in Rats

Xenobiotic-mediated induction of cytochrome P450 (CYP) drug metabolizing enzymes (DMEs) is frequently encountered in drug discovery and can influence disposition, pharmacokinetic, and toxicity profiles. The CYP1A subfamily of DMEs plays a central role in the biotransformation of several drugs and e...

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Bibliographic Details
Main Authors: Michael J. Liguori, Chih-Hung eLee, Hong eLiu, Rita eCiurlionis, Amy C. Ditewig, Stella eDoktor, Mark E. Andracki, Gerard D. Gagne, Jeffrey F. Waring, Kennan C. Marsh, Murali eGopalakrishnan, Eric A.G. Blomme, Yi eYang
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-10-01
Series:Frontiers in Genetics
Subjects:
cytochrome P450
Aryl hydrocarbon receptor
drug metabolism
gene expression analysis
Autoinduction
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00213/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00213/full

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