A Reproducibility-Based Computational Framework Identifies an Inducible, Enhanced Antiviral State in Dendritic Cells from HIV-1 Elite Controllers

A Reproducibility-Based Computational Framework Identifies an Inducible, Enhanced Antiviral State in Dendritic Cells from HIV-1 Elite Controllers

Abstract Background Human immunity relies on the coordinated responses of many cellular subsets and functional states. Inter-individual variations in cellular composition and communication could thus potentially alter host protection. Here, we explore this hypothesis by applying single-cell RNA-sequ...

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Bibliographic Details
Main Authors: Enrique Martin-Gayo, Michael B. Cole, Kellie E. Kolb, Zhengyu Ouyang, Jacqueline Cronin, Samuel W. Kazer, Jose Ordovas-Montanes, Mathias Lichterfeld, Bruce D. Walker, Nir Yosef, Alex K. Shalek, Xu G. Yu
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Genome Biology
Subjects:
HIV-1
Dendritic cell
Single-cell RNA-seq
Single-cell genomics
Elite controller
Adjuvant
Online Access:http://link.springer.com/article/10.1186/s13059-017-1385-x

Internet

http://link.springer.com/article/10.1186/s13059-017-1385-x

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