Estimating dose-specific cell division and apoptosis rates from chemo-sensitivity experiments

Abstract In-vitro chemo-sensitivity experiments are an essential step in the early stages of cancer therapy development, but existing data analysis methods suffer from problems with fitting, do not permit assessment of uncertainty, and can give misleading estimates of cell growth inhibition. We pres...

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Bibliographic Details
Main Authors: Yiyi Liu, Forrest W. Crawford
Format: Article
Language:English
Published: Nature Publishing Group 2018-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-21017-5