Effect of nicastrin on hepatocellular carcinoma proliferation and apoptosis through PI3K/AKT signalling pathway modulation

Effect of nicastrin on hepatocellular carcinoma proliferation and apoptosis through PI3K/AKT signalling pathway modulation

Abstract Background Increasing evidence has proven that the γ-secretase complex plays significant roles in the carcinogenesis of malignancies. However, the independent effect of nicastrin (NCSTN), the largest constituent of the γ-secretase complex, on the progression of hepatocellular carcinoma (HCC...

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Bibliographic Details
Main Authors: Xicheng Wang, Xining Wang, Yunxiuxiu Xu, Maolin Yan, Wenxin Li, Jie Chen, Tao Chen
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Cancer Cell International
Subjects:
NCSTN
Hepatocellular carcinoma
PI3K/AKT
Online Access:http://link.springer.com/article/10.1186/s12935-020-01172-4

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http://link.springer.com/article/10.1186/s12935-020-01172-4

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