β<sub>2</sub>-adrenoceptor blockage induces G<sub>1</sub>/S phase arrest and apoptosis in pancreatic cancer cells via Ras/Akt/NFκB pathway

β<sub>2</sub>-adrenoceptor blockage induces G<sub>1</sub>/S phase arrest and apoptosis in pancreatic cancer cells via Ras/Akt/NFκB pathway

<p>Abstract</p> <p>Background</p> <p>Smoking and stress, pancreatic cancer (PanCa) risk factors, stimulate nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and catecholamines production respectively. NNK and catecholamine bind the β-adrenoceptors and ind...

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Bibliographic Details
Main Authors: Zhang Dong, Ma Qingyong, Wang Zheng, Zhang Min, Guo Kun, Wang Fengfei, Wu Erxi
Format: Article
Language:English
Published: BMC 2011-11-01
Series:Molecular Cancer
Subjects:
β-adrenergic antagonists
G<sub>1</sub>/S phase arrest
apoptosis
Ras
Online Access:http://www.molecular-cancer.com/content/10/1/146

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http://www.molecular-cancer.com/content/10/1/146

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