β<sub>2</sub>-adrenoceptor blockage induces G<sub>1</sub>/S phase arrest and apoptosis in pancreatic cancer cells via Ras/Akt/NFκB pathway
<p>Abstract</p> <p>Background</p> <p>Smoking and stress, pancreatic cancer (PanCa) risk factors, stimulate nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and catecholamines production respectively. NNK and catecholamine bind the β-adrenoceptors and ind...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2011-11-01
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Series: | Molecular Cancer |
Subjects: | |
Online Access: | http://www.molecular-cancer.com/content/10/1/146 |