Progastrin production transitions from Bmi1+/Prox1+ to Lgr5high cells during early intestinal tumorigenesis

Progastrin production transitions from Bmi1+/Prox1+ to Lgr5high cells during early intestinal tumorigenesis

Progastrin is an unprocessed soluble peptide precursor with a well-described tumor-promoting role in colorectal cancer. It is expressed at small levels in the healthy intestinal mucosa, and its expression is enhanced at early stages of intestinal tumor development, with high levels of this peptide i...

Full description

Bibliographic Details
Main Authors: J. Giraud, M. Foroutan, J. Boubaker-Vitre, F. Grillet, Z. Homayed, U. Jadhav, P. Crespy, C. Breuker, J-F. Bourgaux, J. Hazerbroucq, C. Pignodel, B. Brulin, R.A. Shivdasani, P. Jay, F. Hollande, J. Pannequin
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Translational Oncology
Subjects:
Lgr5 (GPR49)
Progastrin
Intestinal stem cells
Adenomas
Tumor initiating cells
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523320304939

Internet

http://www.sciencedirect.com/science/article/pii/S1936523320304939

Similar Items