Analysis of in-vivo LacR-mediated gene repression based on the mechanics of DNA looping.
Interactions of E. coli lac repressor (LacR) with a pair of operator sites on the same DNA molecule can lead to the formation of looped nucleoprotein complexes both in vitro and in vivo. As a major paradigm for loop-mediated gene regulation, parameters such as operator affinity and spacing, represso...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2006-12-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC1762422?pdf=render |