SRA regulates adipogenesis by modulating p38/JNK phosphorylation and stimulating insulin receptor gene expression and downstream signaling.

SRA regulates adipogenesis by modulating p38/JNK phosphorylation and stimulating insulin receptor gene expression and downstream signaling.

The Steroid Receptor RNA Activator (SRA) enhances adipogenesis and increases both glucose uptake and phosphorylation of Akt and FOXO1 in response to insulin. To assess the mechanism, we differentiated ST2 mesenchymal precursor cells that did or did not overexpress SRA into adipocytes using combinati...

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Bibliographic Details
Main Authors: Shannon Liu, Ruichuan Xu, Isabelle Gerin, William P Cawthorn, Ormond A Macdougald, Xiao-Wei Chen, Alan R Saltiel, Ronald J Koenig, Bin Xu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3990642?pdf=render

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http://europepmc.org/articles/PMC3990642?pdf=render

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