Cholesterol Activates Cyclic AMP Signaling in Metaplastic Acinar Cells

Cholesterol Activates Cyclic AMP Signaling in Metaplastic Acinar Cells

Cholesterol is a non-essential metabolite that exerts both structural and signaling functions. However, cholesterol biosynthesis is elevated, and actively supports, pancreatic carcinogenesis. Our previous work showed that statins block the reprogramming of mutant KRAS-expressing acinar cells, that s...

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Bibliographic Details
Main Authors: Francesca Grisan, Martina Spacci, Carlotta Paoli, Andrea Costamagna, Marco Fantuz, Miriam Martini, Konstantinos Lefkimmiatis, Alessandro Carrer
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Metabolites
Subjects:
cyclic adenosine monophosphate (cAMP)
cholesterol
protein kinase A (PKA)
acinar-to-ductal metaplasia (ADM)
Online Access:https://www.mdpi.com/2218-1989/11/3/141

Internet

https://www.mdpi.com/2218-1989/11/3/141

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