Cholesterol Activates Cyclic AMP Signaling in Metaplastic Acinar Cells
Cholesterol is a non-essential metabolite that exerts both structural and signaling functions. However, cholesterol biosynthesis is elevated, and actively supports, pancreatic carcinogenesis. Our previous work showed that statins block the reprogramming of mutant KRAS-expressing acinar cells, that s...
Main Authors: | Francesca Grisan, Martina Spacci, Carlotta Paoli, Andrea Costamagna, Marco Fantuz, Miriam Martini, Konstantinos Lefkimmiatis, Alessandro Carrer |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-02-01
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Series: | Metabolites |
Subjects: | |
Online Access: | https://www.mdpi.com/2218-1989/11/3/141 |
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