Serum amyloid P therapeutically attenuates murine bleomycin-induced pulmonary fibrosis via its effects on macrophages.

Serum amyloid P therapeutically attenuates murine bleomycin-induced pulmonary fibrosis via its effects on macrophages.

Macrophages promote tissue remodeling but few mechanisms exist to modulate their activity during tissue fibrosis. Serum amyloid P (SAP), a member of the pentraxin family of proteins, signals through Fcgamma receptors which are known to affect macrophage activation. We determined that IPF/UIP patient...

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Bibliographic Details
Main Authors: Lynne A Murray, Rogerio Rosada, Ana Paula Moreira, Amrita Joshi, Michael S Kramer, David P Hesson, Rochelle L Argentieri, Susan Mathai, Mridu Gulati, Erica L Herzog, Cory M Hogaboam
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2837381?pdf=render

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http://europepmc.org/articles/PMC2837381?pdf=render

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