splitGFP Technology Reveals Dose-Dependent ER-Mitochondria Interface Modulation by α-Synuclein A53T and A30P Mutants

splitGFP Technology Reveals Dose-Dependent ER-Mitochondria Interface Modulation by α-Synuclein A53T and A30P Mutants

Familial Parkinson’s disease (PD) is associated with duplication or mutations of α-synuclein gene, whose product is a presynaptic cytosolic protein also found in mitochondria and in mitochondrial-associated ER membranes. We have originally shown the role of α-syn as a mod...

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Bibliographic Details
Main Authors: Tito Calì, Denis Ottolini, Mattia Vicario, Cristina Catoni, Francesca Vallese, Domenico Cieri, Lucia Barazzuol, Marisa Brini
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cells
Subjects:
Parkinson’s disease
alpha-synuclein
calcium
mitochondria
ER-mitochondria contact sites
Online Access:https://www.mdpi.com/2073-4409/8/9/1072

Internet

https://www.mdpi.com/2073-4409/8/9/1072

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