Hypoxia Imaging and Adaptive Radiotherapy: A State-of-the-Art Approach in the Management of Glioma

Hypoxia Imaging and Adaptive Radiotherapy: A State-of-the-Art Approach in the Management of Glioma

Severe hypoxia [oxygen partial pressure (pO2) below 5–10 mmHg] is more frequent in glioblastoma multiforme (GBM) compared to lower-grade gliomas. Seminal studies in the 1950s demonstrated that hypoxia was associated with increased resistance to low–linear energy transfer (LET) ionizing radiation. In...

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Bibliographic Details
Main Authors: Michael Gérard, Aurélien Corroyer-Dulmont, Paul Lesueur, Solène Collet, Michel Chérel, Mickael Bourgeois, Dinu Stefan, Elaine Johanna Limkin, Cécile Perrio, Jean-Sébastien Guillamo, Bernard Dubray, Myriam Bernaudin, Juliette Thariat, Samuel Valable
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Medicine
Subjects:
glioblastoma
hypoxia
imaging
PET
MRI
radiation therapy
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2019.00117/full

Internet

https://www.frontiersin.org/article/10.3389/fmed.2019.00117/full

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