Inflammatory-Related P62 Triggers Malignant Transformation of Mesenchymal Stem Cells through the Cascade of CUDR-CTCF-IGFII-RAS Signaling

Inflammatory-Related P62 Triggers Malignant Transformation of Mesenchymal Stem Cells through the Cascade of CUDR-CTCF-IGFII-RAS Signaling

Inflammatory and autophagy-related gene P62 is highly expressed in most human tumor tissues. Herein, we demonstrate that P62 promotes human mesenchymal stem cells’ malignant transformation via the cascade of P62-tumor necrosis factor alpha (TNF-α)-CUDR-CTCF-insulin growth factor II (IGFII)-H-Ras sig...

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Bibliographic Details
Main Authors: Xiaoru Xin, Chen Wang, Zhuojia Lin, Jie Xu, Yanan Lu, Qiuyu Meng, Xiaonan Li, Yuxin Yang, Qidi Zheng, Xin Gui, Tianming Li, Hu Pu, Wujun Xiong, Jiao Li, Song Jia, Dongdong Lu
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
P62
TNF-α
inflammation
mesenchymal stem cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253118300325

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http://www.sciencedirect.com/science/article/pii/S2162253118300325

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