Facile synthesis of indole-pyrimidine hybrids and evaluation of their anticancer and antimicrobial activity

Facile synthesis of indole-pyrimidine hybrids and evaluation of their anticancer and antimicrobial activity

The paper describes the facile synthesis of new N-cyclopropyl-1-methyl-1H-indole-2-carboxamide derivatives bearing substituted 2-amino pyrimidine moiety at position-3 of the indole ring. All the intermediate and title compounds were characterized adeptly by 1H NMR, 13C NMR, ESI–MS and elemental anal...

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Bibliographic Details
Main Authors: Nikhila Gokhale, Udayakumar Dalimba, Manjunatha Kumsi
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:Journal of Saudi Chemical Society
Subjects:
Indole
Pyrimidine
HATU
Claisen–Schmidt condensation
Anticancer activity
Antimicrobial studies
Online Access:http://www.sciencedirect.com/science/article/pii/S1319610315001131

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http://www.sciencedirect.com/science/article/pii/S1319610315001131

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