Metformin inhibits proliferation and cytotoxicity and induces apoptosis via AMPK pathway in CD19-chimeric antigen receptor-modified T cells

Metformin inhibits proliferation and cytotoxicity and induces apoptosis via AMPK pathway in CD19-chimeric antigen receptor-modified T cells

Qian Mu,1,2,* Miao Jiang,1,* Yuzhu Zhang,1 Fei Wu,1 Hui Li,1 Wen Zhang,1 Fang Wang,1 Jiang Liu,1 Liang Li,1 Dongshan Wang,3 Wenjuan Wang,1 Shiwu Li,1 Haibo Song,4 Dongqi Tang1 1Gene and Immunotherapy Center, The Second Hospital of Shandong University, Jinan, People’s Republic of China; 2D...

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Bibliographic Details
Main Authors: Mu Q, Jiang M, Zhang Y, Wu F, Li H, Zhang W, Wang F, Liu J, Li L, Wang D, Wang W, Li S, Song H, Tang D
Format: Article
Language:English
Published: Dove Medical Press 2018-04-01
Series:OncoTargets and Therapy
Subjects:
Chimeric antigen receptor
metformin
proliferation
apoptosis
cytotoxicity
AMPK
Online Access:https://www.dovepress.com/metformin-inhibits-proliferation-and-cytotoxicity-and-induces-apoptosi-peer-reviewed-article-OTT

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https://www.dovepress.com/metformin-inhibits-proliferation-and-cytotoxicity-and-induces-apoptosi-peer-reviewed-article-OTT

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