Constitutive Vagus Nerve Activation Modulates Immune Suppression in Sepsis Survivors

Constitutive Vagus Nerve Activation Modulates Immune Suppression in Sepsis Survivors

Patients surviving a septic episode exhibit persistent immune impairment and increased mortality due to enhanced vulnerability to infections. In the present study, using the cecal ligation and puncture (CLP) model of polymicrobial sepsis, we addressed the hypothesis that altered vagus nerve activity...

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Bibliographic Details
Main Authors: Minakshi Rana, Yurong Fei-Bloom, Myoungsun Son, Andrea La Bella, Mahendar Ochani, Yaakov A. Levine, Pui Yan Chiu, Ping Wang, Sangeeta S. Chavan, Bruce T. Volpe, Barbara Sherry, Betty Diamond
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
innate immune response
sepsis survivors
vagus tonic activity
CD4+ ChAT+ T cell
TNFα
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02032/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02032/full

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