PRMT5 Is Required for Bovine Leukemia Virus Infection In Vivo and Regulates BLV Gene Expression, Syncytium Formation, and Glycosylation In Vitro

PRMT5 Is Required for Bovine Leukemia Virus Infection In Vivo and Regulates BLV Gene Expression, Syncytium Formation, and Glycosylation In Vitro

Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leukosis, which is the most common neoplastic disease of cattle and is closely related to human T-cell leukemia viruses. We investigated the role of a new host protein, PRMT5, in BLV infection. We found that PRMT5 is overexpressed...

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Bibliographic Details
Main Authors: Wlaa Assi, Tomoya Hirose, Satoshi Wada, Ryosuke Matsuura, Shin-nosuke Takeshima, Yoko Aida
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Viruses
Subjects:
bovine leukemia virus
PRMT5
proviral load
BLV gene expression
PRMT5 inhibitor
gp51
Online Access:https://www.mdpi.com/1999-4915/12/6/650

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https://www.mdpi.com/1999-4915/12/6/650

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