The ion selectivity filter is not an activation gate in TRPV1-3 channels
Activation of TRPV1 channels in sensory neurons results in opening of a cation permeation pathway that triggers the sensation of pain. Opening of TRPV1 has been proposed to involve two gates that appear to prevent ion permeation in the absence of activators: the ion selectivity filter on the externa...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2019-11-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/51212 |