Membrane-bound sn-1,2-diacylglycerols explain the dissociation of hepatic insulin resistance from hepatic steatosis in MTTP knockout mice

Membrane-bound sn-1,2-diacylglycerols explain the dissociation of hepatic insulin resistance from hepatic steatosis in MTTP knockout mice

Microsomal triglyceride transfer protein (MTTP) deficiency results in a syndrome of hypolipidemia and accelerated NAFLD. Animal models of decreased hepatic MTTP activity have revealed an unexplained dissociation between hepatic steatosis and hepatic insulin resistance. Here, we performed comprehensi...

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Bibliographic Details
Main Authors: Abudukadier Abulizi, Daniel F. Vatner, Zhang Ye, Yongliang Wang, Joao-Paulo Camporez, Dongyan Zhang, Mario Kahn, Kun Lyu, Alaa Sirwi, Gary W. Cline, M. Mahmood Hussain, Patricia Aspichueta, Varman T. Samuel, Gerald I. Shulman
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Journal of Lipid Research
Subjects:
lipids
liver
metabolic disease
nonalcoholic fatty liver disease
drug therapy
liver microsomal triglyceride transfer protein
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520600190

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http://www.sciencedirect.com/science/article/pii/S0022227520600190

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