Irisin Attenuates Myocardial Ischemia/Reperfusion Injury and Improves Mitochondrial Function Through AMPK Pathway in Diabetic Mice

Irisin Attenuates Myocardial Ischemia/Reperfusion Injury and Improves Mitochondrial Function Through AMPK Pathway in Diabetic Mice

AimsSeveral recent reports have shown irisin protects the heart against ischemia/reperfusion injury. However, the effect of irisin on I/R injury in diabetic mice has not been described. The present study was designed to investigate the role of irisin in myocardial ischemia-reperfusion (MI/R) injury...

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Bibliographic Details
Main Authors: Chao Xin, Zheng Zhang, Guojie Gao, Liping Ding, Chao Yang, Chengzhu Wang, Yanjun Liu, Yufei Guo, Xueqing Yang, Lijuan Zhang, Lina Zhang, Yi Liu, Zhitao Jin, Ling Tao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Pharmacology
Subjects:
irisin
ischemia/reperfusion
mitochondria
AMPK
diabetes
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.565160/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.565160/full

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