Differential effects of class I isoform histone deacetylase depletion and enzymatic inhibition by belinostat or valproic acid in HeLa cells

Differential effects of class I isoform histone deacetylase depletion and enzymatic inhibition by belinostat or valproic acid in HeLa cells

<p>Abstract</p> <p>Background</p> <p>Histone acetylation is an epigenetic modification involved in the regulation of gene expression, balanced by histone acetyl transferases and histone deacetylase (HDAC) enzymes. HDAC inhibitors (HDACi) induce growth arrest and cell de...

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Bibliographic Details
Main Authors: Dejligbjerg Marielle, Grauslund Morten, Litman Thomas, Collins Laura, Qian Xiaozhong, Jeffers Michael, Lichenstein Henri, Jensen Peter, Sehested Maxwell
Format: Article
Language:English
Published: BMC 2008-09-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/7/1/70

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http://www.molecular-cancer.com/content/7/1/70

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