NADPH oxidase 2-derived reactive oxygen species mediate FFAs-induced dysfunction and apoptosis of β-cells via JNK, p38 MAPK and p53 pathways.

NADPH oxidase 2-derived reactive oxygen species mediate FFAs-induced dysfunction and apoptosis of β-cells via JNK, p38 MAPK and p53 pathways.

Dysfunction of β-cell is one of major characteristics in the pathogenesis of type 2 diabetes. The combination of obesity and type 2 diabetes, characterized as 'diabesity', is associated with elevated plasma free fatty acids (FFAs). Oxidative stress has been implicated in the pathogenesis o...

Full description

Bibliographic Details
Main Authors: Huiping Yuan, Xiaoyong Zhang, Xiuqing Huang, Yonggang Lu, Weiqing Tang, Yong Man, Shu Wang, Jianzhong Xi, Jian Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3012098?pdf=render

Internet

http://europepmc.org/articles/PMC3012098?pdf=render

Similar Items