Inert and seed-competent tau monomers suggest structural origins of aggregation

Inert and seed-competent tau monomers suggest structural origins of aggregation

Tauopathies feature progressive accumulation of tau amyloids. Pathology may begin when these amplify from a protein template, or seed, whose structure is unknown. We have purified and characterized distinct forms of tau monomer—inert (Mi) and seed-competent (Ms). Recombinant Ms triggered intracellul...

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Bibliographic Details
Main Authors: Hilda Mirbaha, Dailu Chen, Olga A Morazova, Kiersten M Ruff, Apurwa M Sharma, Xiaohua Liu, Mohammad Goodarzi, Rohit V Pappu, David W Colby, Hamid Mirzaei, Lukasz A Joachimiak, Marc I Diamond
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-07-01
Series:eLife
Subjects:
tau
prion
conformation
seeding
amyloid
Online Access:https://elifesciences.org/articles/36584

Internet

https://elifesciences.org/articles/36584

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