Aberrant populations of circulating T follicular helper cells and regulatory B cells underlying idiopathic pulmonary fibrosis

Aberrant populations of circulating T follicular helper cells and regulatory B cells underlying idiopathic pulmonary fibrosis

Abstract Background T follicular helper (Tfh) cells have been identified as a new category of helper T cells, which express CXCR5 on their surface and induce the production of antigen-specific antibodies. Many investigations have found morbid proliferation and/or activation of Tfh cells in systemic...

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Bibliographic Details
Main Authors: Yuichiro Asai, Hirofumi Chiba, Hirotaka Nishikiori, Ryuta Kamekura, Hayato Yabe, Shun Kondo, Satsuki Miyajima, Katsunori Shigehara, Shingo Ichimiya, Hiroki Takahashi
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Respiratory Research
Subjects:
Idiopathic pulmonary fibrosis (IPF)
T follicular helper cell (Tfh cell)
regulatory B cell (Breg cell)
CXCR5 (C-X-C motif chemokine receptor 5)
ICOS (inducible co-stimulatory molecule)
PD-1 (programmed death 1)
Online Access:http://link.springer.com/article/10.1186/s12931-019-1216-6

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http://link.springer.com/article/10.1186/s12931-019-1216-6

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