Ancient but Not Forgotten: New Insights Into MPEG1, a Macrophage Perforin-Like Immune Effector

Ancient but Not Forgotten: New Insights Into MPEG1, a Macrophage Perforin-Like Immune Effector

Macrophage-expressed gene 1 [MPEG1/Perforin-2 (PRF2)] is an ancient metazoan protein belonging to the Membrane Attack Complex/Perforin (MACPF) branch of the MACPF/Cholesterol Dependent Cytolysin (CDC) superfamily of pore-forming proteins (PFPs). MACPF/CDC proteins are a large and extremely diverse s...

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Bibliographic Details
Main Authors: Charles Bayly-Jones, Siew Siew Pang, Bradley A. Spicer, James C. Whisstock, Michelle A. Dunstone
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
MACPF/CDC
MACPF domain
pore-forming protein
immune effector
immunology
PRF2
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.581906/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.581906/full

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