Precision dosing of intravenous busulfan in pediatric hematopoietic stem cell transplantation: Results from a multicenter population pharmacokinetic study

Precision dosing of intravenous busulfan in pediatric hematopoietic stem cell transplantation: Results from a multicenter population pharmacokinetic study

Abstract Busulfan (Bu) is a common component of conditioning regimens before hematopoietic stem cell transplantation (HSCT) and is known for high interpatient pharmacokinetic (PK) variability. This study aimed to develop and externally validate a multicentric, population PK (PopPK) model for intrave...

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Bibliographic Details
Main Authors: Khalil Ben Hassine, Tiago Nava, Yves Théoret, Christa E. Nath, Youssef Daali, Nastya Kassir, Victor Lewis, Robbert G. M. Bredius, Peter J. Shaw, Henrique Bittencourt, Maja Krajinovic, Chakradhara Rao Satyanarayana Uppugunduri, Marc Ansari
Format: Article
Language:English
Published: Wiley 2021-09-01
Series:CPT: Pharmacometrics & Systems Pharmacology
Online Access:https://doi.org/10.1002/psp4.12683

Internet

https://doi.org/10.1002/psp4.12683

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