Alantolactone, a natural sesquiterpene lactone, has potent antitumor activity against glioblastoma by targeting IKKβ kinase activity and interrupting NF-κB/COX-2-mediated signaling cascades

Alantolactone, a natural sesquiterpene lactone, has potent antitumor activity against glioblastoma by targeting IKKβ kinase activity and interrupting NF-κB/COX-2-mediated signaling cascades

Abstract Background Glioblastoma multiforme (GBM) is one of the most refractory and palindromic central nervous system (CNS) neoplasms, and current treatments have poor effects in GBM patients. Hence, the identification of novel therapeutic targets and the development of effective treatment strategi...

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Bibliographic Details
Main Authors: Xun Wang, Zhenlong Yu, Chao Wang, Wei Cheng, Xiangge Tian, Xiaokui Huo, Yan Wang, Chengpeng Sun, Lei Feng, Jinshan Xing, Yulong Lan, Dongdong Sun, Qingjuan Hou, Baojing Zhang, Xiaochi Ma, Bo Zhang
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Alantolactone
Glioblastoma multiforme
Blood-brain barrier
Cox-2
IKKβ/NF-κB
Online Access:http://link.springer.com/article/10.1186/s13046-017-0563-8

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http://link.springer.com/article/10.1186/s13046-017-0563-8

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