Altered DNA methylation in leukocytes with trisomy 21.

Altered DNA methylation in leukocytes with trisomy 21.

The primary abnormality in Down syndrome (DS), trisomy 21, is well known; but how this chromosomal gain produces the complex DS phenotype, including immune system defects, is not well understood. We profiled DNA methylation in total peripheral blood leukocytes (PBL) and T-lymphocytes from adults wit...

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Bibliographic Details
Main Authors: Kristi Kerkel, Nicole Schupf, Kota Hatta, Deborah Pang, Martha Salas, Alexander Kratz, Mark Minden, Vundavalli Murty, Warren B Zigman, Richard P Mayeux, Edmund C Jenkins, Ali Torkamani, Nicholas J Schork, Wayne Silverman, B Anne Croy, Benjamin Tycko
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-11-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2987931?pdf=render

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http://europepmc.org/articles/PMC2987931?pdf=render

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