Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis.

Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis.

Trypanosoma brucei relies on an essential Variant Surface Glycoprotein (VSG) coat for survival in the mammalian bloodstream. High VSG expression within an expression site body (ESB) is mediated by RNA polymerase I (Pol I), which in other eukaryotes exclusively transcribes ribosomal RNA genes (rDNA)....

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Bibliographic Details
Main Authors: Louise E Kerry, Elaine E Pegg, Donald P Cameron, James Budzak, Gretchen Poortinga, Katherine M Hannan, Ross D Hannan, Gloria Rudenko
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-03-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC5354456?pdf=render

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http://europepmc.org/articles/PMC5354456?pdf=render

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