Pathogen to commensal? Longitudinal within-host population dynamics, evolution, and adaptation during a chronic >16-year Burkholderia pseudomallei infection.

Pathogen to commensal? Longitudinal within-host population dynamics, evolution, and adaptation during a chronic >16-year Burkholderia pseudomallei infection.

Although acute melioidosis is the most common outcome of Burkholderia pseudomallei infection, we have documented a case, P314, where disease severity lessened with time, and the pathogen evolved towards a commensal relationship with the host. In the current study, we used whole-genome sequencing to...

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Bibliographic Details
Main Authors: Talima Pearson, Jason W Sahl, Crystal M Hepp, Karthik Handady, Heidie Hornstra, Adam J Vazquez, Erik Settles, Mark Mayo, Mirjam Kaestli, Charles H D Williamson, Erin P Price, Derek S Sarovich, James M Cook, Spenser R Wolken, Richard A Bowen, Apichai Tuanyok, Jeffrey T Foster, Kevin P Drees, Timothy J Kidd, Scott C Bell, Bart J Currie, Paul Keim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-03-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008298

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https://doi.org/10.1371/journal.ppat.1008298

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