Silibinin Restores NAD+ Levels and Induces the SIRT1/AMPK Pathway in Non-Alcoholic Fatty Liver

Silibinin Restores NAD+ Levels and Induces the SIRT1/AMPK Pathway in Non-Alcoholic Fatty Liver

Nicotinamide adenine dinucleotide (NAD+) homeostasis is emerging as a key player in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and is tightly linked to the SIRT1/5’-AMP-activated protein kinase (AMPK) pathway. Silibinin, the main component of silymarin, has been proposed as a nutr...

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Bibliographic Details
Main Authors: Federico Salomone, Ignazio Barbagallo, Justyna Godos, Vincenzo Lembo, Walter Currenti, Diana Cinà, Roberto Avola, Nicolantonio D’Orazio, Filomena Morisco, Fabio Galvano, Giovanni Li Volti
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:Nutrients
Subjects:
silibinin
NAD+
SIRT1
AMPK
lipogenesis
Online Access:https://www.mdpi.com/2072-6643/9/10/1086

Internet

https://www.mdpi.com/2072-6643/9/10/1086

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