Reduction of thalamic and cortical Ih by deletion of TRIP8b produces a mouse model of human absence epilepsy

Reduction of thalamic and cortical Ih by deletion of TRIP8b produces a mouse model of human absence epilepsy

Absence seizures occur in several types of human epilepsy and result from widespread, synchronous feedback between the cortex and thalamus that produces brief episodes of loss of consciousness. Genetic rodent models have been invaluable for investigating the pathophysiological basis of these seizure...

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Bibliographic Details
Main Authors: Robert J. Heuermann, Thomas C. Jaramillo, Shui-Wang Ying, Benjamin A. Suter, Kyle A. Lyman, Ye Han, Alan S. Lewis, Thomas G. Hampton, Gordon M.G. Shepherd, Peter A. Goldstein, Dane M. Chetkovich
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Neurobiology of Disease
Subjects:
TRIP8b
HCN channels
Ih
Absence epilepsy
Neocortex
Thalamus
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115300632

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http://www.sciencedirect.com/science/article/pii/S0969996115300632

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