MyoD Regulates Skeletal Muscle Oxidative Metabolism Cooperatively with Alternative NF-κB

MyoD Regulates Skeletal Muscle Oxidative Metabolism Cooperatively with Alternative NF-κB

MyoD is a key regulator of skeletal myogenesis that directs contractile protein synthesis, but whether this transcription factor also regulates skeletal muscle metabolism has not been explored. In a genome-wide ChIP-seq analysis of skeletal muscle cells, we unexpectedly observed that MyoD directly b...

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Bibliographic Details
Main Authors: Jonathan Shintaku, Jennifer M. Peterson, Erin E. Talbert, Jin-Mo Gu, Katherine J. Ladner, Dustin R. Williams, Kambiz Mousavi, Ruoning Wang, Vittorio Sartorelli, Denis C. Guttridge
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Cell Reports
Subjects:
mitochondrial biogenesis
oxidative metabolism
skeletal muscle
MyoD
NF-kappaB
RelB
ppargc1b
PGC-1beta
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716312153

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http://www.sciencedirect.com/science/article/pii/S2211124716312153

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