On the SARS-CoV-2 “Variolation Hypothesis”: No Association Between Viral Load of Index Cases and COVID-19 Severity of Secondary Cases

On the SARS-CoV-2 “Variolation Hypothesis”: No Association Between Viral Load of Index Cases and COVID-19 Severity of Secondary Cases

Background: Emerging evidence supports the “variolation hypothesis” in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), but the derivative idea that the viral load of index cases may predict disease severity in secondary cases could be unsubstantiated. We assessed whether the prevalence...

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Bibliographic Details
Main Authors: Mattia Trunfio, Bianca Maria Longo, Francesca Alladio, Francesco Venuti, Francesco Cerutti, Valeria Ghisetti, Stefano Bonora, Giovanni Di Perri, Andrea Calcagno
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Microbiology
Subjects:
SARS-CoV-2
COVID-19
viral inoculum
viral amount
cycle threshold
disease severity
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.646679/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2021.646679/full

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