The Commensal Microbiota Enhances ADP-Triggered Integrin α<sub>IIb</sub>β<sub>3</sub> Activation and von Willebrand Factor-Mediated Platelet Deposition to Type I Collagen

The Commensal Microbiota Enhances ADP-Triggered Integrin α<sub>IIb</sub>β<sub>3</sub> Activation and von Willebrand Factor-Mediated Platelet Deposition to Type I Collagen

The commensal microbiota is a recognized enhancer of arterial thrombus growth. While several studies have demonstrated the prothrombotic role of the gut microbiota, the molecular mechanisms promoting arterial thrombus growth are still under debate. Here, we demonstrate that germ-free (GF) mice, whic...

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Bibliographic Details
Main Authors: Klytaimnistra Kiouptsi, Sven Jäckel, Eivor Wilms, Giulia Pontarollo, Jana Winterstein, Cornelia Karwot, Kathrin Groß, Kerstin Jurk, Christoph Reinhardt
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
microbiota
germ-free
von Willebrand factor
Toll-like receptor-2
platelets
α<sub>IIb</sub>β<sub>3</sub>
Online Access:https://www.mdpi.com/1422-0067/21/19/7171

Internet

https://www.mdpi.com/1422-0067/21/19/7171

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