Blood flow guides sequential support of neutrophil arrest and diapedesis by PILR-β1 and PILR-α

Blood flow guides sequential support of neutrophil arrest and diapedesis by PILR-β1 and PILR-α

Arrest of rapidly flowing neutrophils in venules relies on capturing through selectins and chemokine-induced integrin activation. Despite a long-established concept, we show here that gene inactivation of activating paired immunoglobulin-like receptor (PILR)-β1 nearly halved the efficiency of neutro...

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Bibliographic Details
Main Authors: Yu-Tung Li, Debashree Goswami, Melissa Follmer, Annette Artz, Mariana Pacheco-Blanco, Dietmar Vestweber
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-08-01
Series:eLife
Subjects:
leukocyte extravasation
neutrophils
inflammation
endothelium
integrins
Online Access:https://elifesciences.org/articles/47642

Internet

https://elifesciences.org/articles/47642

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